Apoptosis in Immunology PDF – Current Topics in Microbiology and Immunology

Apoptosis in Immunology PDF - Current Topics in Microbiology and Immunology



4.82 MB PDF

   Free Download Here


Preface

In any movement of their life, immune cells, especially T and B lymphocytes, are confronted with an essential choice: to continue their existence or to commit a sort of metabolic suicide that is referred to as apoptosis or programmed cell death. In contrast to most philosophers, lymphocytes and their precursors are constantly susceptible to suicide, and it even appears that the usual cause of T or B cell elimination is suicide rather than death from natural causes, accidents or murder. This book provides a vast overview of lymphocytes suicide: external triggers and internal motives leading to suicidal impulses, accomplices in self-destruction, weapons implicated in self-execution, removal of dead bodies and pharmacological prevention of suicide.
Most of the chapters in this book are devoted to the physiology of apoptosis. The goal is to unmask the external triggers of apoptosis, unravel the signal transduction processes involved therein and describe the role of oncogenes, “death genes” and effector molecules in the apoptotic cascade. The remaining chapters deal with the pathophysiological aspects of lymphocyte apoptosis, namely, as a host contribution to HIV-induced lymphopenia, and therapeutic strategies for the avoidance of lymphocyte death.
We are confident that this compendium will contribute to the exploration of cellular suicide, not only from a basic scientist’s viewpoint but also with regard to the possible clinical implications of apoptosis (dys)regulation. Far from having a depressing effect on the reader, cellular suicide may thus provide a source of both intellectual excitement and therapeutic inspiration.


If you found this book helpful then please like, subscribe and share.

Disclaimer
This site complies with DMCA Digital Copyright Laws. Please bear in mind that we do not own copyrights to this book / software. We’re sharing this with our audience ONLY for educational purpose and we highly encourage our visitors to purchase original licensed software / Books. If someone with copyrights wants us to remove this software / Book, please contact us immediately. You may send an email to [email protected] for all DMCA/Removal Requests.

LEAVE A REPLY

Please enter your comment!
Please enter your name here

This site uses Akismet to reduce spam. Learn how your comment data is processed.