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USMLE Road Map Immunology PDF

USMLE Road Map Immunology PDF

USMLE Road Map Immunology PDF


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Table of Contents

Using the Road Map Series for Successful Review . . . . . . . . . . . . . . . . . . . . . . . vii
Acknowledgments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . viii

MECHANISMS AND CONSEQUENCES OF IMMUNE RECOGNITION
1. Innate Immunity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1
2. Adaptive Immunity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .14
3. Antigens and Antibodies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .28
4. Immunoglobulin Gene Expression . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .40
5. Antigen Recognition by Antibody . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .52
6. T Cell Recognition of and Response to Antigen . . . . . . . . . . . . . . . . . . . . . .64
7. Major Histocompatibility Complex . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .77

DEVELOPMENT OF IMMUNE EFFECTOR MECHANISMS
8. Complement . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .91
9. B Cell Differentiation and Function . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .104
10. T Cell Differentiation and Function . . . . . . . . . . . . . . . . . . . . . . . . . . . . .118
11. Regulation of Immune Responses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .130
12. Cytokines . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .137

IMMUNITY IN HEALTH AND DISEASE
13. Immune Tissue Injury . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .149
14. Protective Immunity and Vaccines . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .164
15. Immune Deficiency States . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .175
16. Autotolerance and Autoimmunity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .192
17. Transplantation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .204
Appendices . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .217
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .219


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