The Liver Biology and Pathobiology 5th Edition PDF

The Liver Biology and Pathobiology 5th Edition PDF



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Preface

Predictions stated in previous editions of The Liver: Biology and Pathobiology (1982, 1988, 1994, and 1999) have consistently come to pass at a faster rate than had been anticipated. Major advances in genetics, immunology, virology, chemistry, biophysics, and structural, molecular, and cellular biology increasingly affect our understanding of liver function and disease. The near future promises additional developments resulting from the sequencing of the human genome, proteomics, small RNAs, and advances in combinatorial chemistry, micro-imaging, stem cell biology, and other areas of research.
The challenge addressed by this book has not changed since the Preface to the First Edition was written in 1982:
The amazing advances in fundamental biology that have occurred within the past two decades have brought hepatology and other disciplines into new, uncharted and exciting waters. The dramatic changes in biology will profoundly influence our ability to diagnose, treat, and prevent liver disease. How can a student of the liver and its disease maintain a link to these exciting advances? Most physicians lack the time to take post-graduate courses in basic biology; most basic researchers lack an understanding of liver physiology and disease. This book strives to bridge the ever-increasing gap between the amazing advances in basic biology and their application to liver structure, function, and disease.
A problem arises. How can a new edition remain reasonable in cost and size and still present essential background information, which has not changed since the last edition, as well as the panoply of major new contributions to our understanding of liver disease? In the Fourth Edition, we introduced a novel solution which has been expanded in the current Fifth Edition. The Fourth Edition emphasized exciting important new concepts and discoveries of the previous five years, and background information and references from the previous edition were provided on an open web site.
Now, in collaboration with our new publisher, Wiley-Blackwell, we have provided 17 chapters from the Fourth Edition on the web site GastroHep.com. These are freely available and we have cross-referenced the new text to these chapters. They are designated by [insert computer screen symbol] and web site chapter numbers W-1 through W-17 when cited in the text. Therefore, readers can obtain new information in the printed Fifth Edition and background information through GastroHep.com.
The Fifth Edition includes 60 NEW chapters and 14 chapters are on the web site that present major progress as achieved in the laboratory and clinic. All other chapters either have been completely revised or appear on the web site. Harvey Alter, David Cohen and Allan Wolkoff have become Associate Editors. Previous editions included a section entitled “Horizons”, which presented advances of extraordinary nature in areas of potentially major importance to the liver. Virtually all of these fields have rapidly expanded and become topics for future chapters. Fifteen new “Horizons” are presented in this edition. One may safely predict that their impact on hepatology will also be considerable.
As stated in the Preface to the Third and Fourth Editions:
The amazing advance in science proceeds at an ever-increasing pace. The implications for students of liver disease are considerable. The authors and editors will have achieved our goals if the reader finds within this volume glimpses into the current state and future direction of our discipline and perspectives that lead to better understanding of liver function and disease.


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