Salivary Gland Development and Regeneration PDF – Advances in Research and Clinical Approaches to Functional Restoration

Salivary Gland Development and Regeneration PDF

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Rome was not built in a day, as the English playwright John Heywood famously wrote. Innovation and advancement in the field of salivary gland regeneration is one of the great examples that reflects this sentiment. The first research article available on this topic through the US National Library of Medicine dates back to 1950. The article, entitled “Regeneration in the Submaxillary Gland of the Rat,” by B.B. Milstein in 1950, cites Van Podwyssozki as the first to describe regeneration of organs of small animals as long ago as 1886 and regeneration of the salivary glands (Die Regeneration an den Speicheldrusen) in 1887.
Since the 1950s, an ever-expanding literature and diversified approaches aimed at functional restorations have mirrored strong interest and attention to this particular subject of research. Journal articles dealing with autoimmune Sjögren’s syndrome, effects of radiation, and ductal ligation models in rats and mice appeared in the early 1980s, followed by research on neural regulation of secretion and effectiveness of epidermal growth factor in wound healing models and glandular regeneration in the late 1980s through the mid-1990s.
In 1995, the late Dr. Michael Humphreys published his well-known review article entitled “Saliva and growth factors: the fountain of youth resides in us all,” which emphasized the vital importance of growth factors in oral/systemic health and glandular repair/regeneration. Histological analyses of glandular architecture and development were established by Dr. Robert Redman, the author of Chap. 4 of this volume. With the turn of a new century, molecular and cellular mechanisms of branching morphogenesis and glandular
development were further investigated and pioneered by Drs. Kenneth M. Yamada and Matthew P. Hoffman, whose work provided foundations for the application of tissue engineering concepts and methodologies to salivary regeneration. Outstanding contributions by Dr. Bruce J. Baum to the field of tissue engineering and gene therapy have ultimately been solidified in applications such as clinical trials involving AAV2-mediated human aquaporin-1 delivery in recent years. Investigation of ductal ligation models, irradiation models, and Sjögren’s syndrome NOD models dominated interest in the field until around 2010, when stem cell research in vitro and in vivo reignited research interest and passion in salivary gland regeneration.
In the current era, the authors and coauthors in this book, who are renowned researchers, dentists, and surgeons in the field, have spearheaded efforts to discover the underlying pathogenesis of xerostomia and innovative approaches to restore secretory function. I am proud to present their collective efforts and years of their research outcomes revealed in their book chapters, which will establish another significant milestone in the history and tradition of studies on glandular regeneration.
This book begins with the description of fundamental and molecular processes occurring during salivary gland organogenesis/branching morphogenesis and molecular communications among epithelial, mesenchymal, endothelial, and neuronal cells for cellular differentiation and organ development (Chap. 1, Dr. Lombaert). The importance of understanding the communications and simulating optimal environments in glandular repair and regeneration is further discussed under Future Prospects.

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