Molecular Medicine Genomics to Personalized Healthcare PDF

Molecular Medicine Genomics to Personalized Healthcare PDF



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Preface

There have been six major developments since the third edition of Molecular Medicine:
1. Growth of omics particularly genomics;
2. The start of whole genome sequencing for patient care;
3. Broader acceptance of personalized medicine in selecting the right drug or its dose based on molecular typing of patient DNA;
4. A shift to somatic cell genetics particularly solid cancers;
5. Expansion in the Direct-to-Consumer DNA testing market, and
6. Recognition of a roadblock to the effective translation of molecular medicine research including the need for better bioinformatics to understand the significance of DNA variants and the many changes in DNA, RNA or even chromosomes now detectable through omics strategies.
The title to this edition has subtly changed to include reference to personalized medicine, which, as explained in Chapter 1, is not new with some taking it as another example of inappropriate hype. Nevertheless, it attracts attention and so is useful if it helps to push the translational components of molecular medicine and ensures the next generation of health professionals are suitably engaged. The first edition was subtitled: An introductory text for students. This was left out in subsequent editions on the assumption that the clinical applications of DNA-based medicine were being taught in the universities. However, new developments in omics are occurring rapidly, and there is some concern that their educational aspects are not being addressed in many of the modern curricula. Governments and major research funders are attempting to fast track the translational aspects of molecular medicine but this will not be enough without linking their initiatives to the education of tomorrow’s health practitioners.
This edition no longer has a Glossary or Methodology because this material can be found on the Internet. Nevertheless, Methodology remains important, since patients and families are interested and will go to the Internet, so the health professional may be asked technical questions. In the era of open yet personalized medicine, there is no reason why the health professional and the patient or family cannot sit down and work through the technical issues using the computer as a component of the consultation.


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