Molecular Genetics of Hypertension PDF



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Preface

Essential hypertension is a complex quantitative trait under polygenic control. The identification of genes responsible for high blood pressure remains a major challenge because of complex gene-environment interactions, which have proved difficult to dissect with the use of existing genetic and statistical paradigms. However, regardless of the difficulties, identification of the major genes responsible for high blood pressure is important, as this will provide a mechanistic classification of the common hypertensive phenotype, diagnostic markers for individuals and families who are at greatest risk of end-organ complications such as stroke, cardiac ischemia or chronic renal failure and, ultimately, will guide new pharmacogenomic stategies with drug therapies tailored to the underlying primary genetic abnormalities.


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