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Heart Failure Bench to Bedside PDF – Contemporary Cardiology

Heart Failure Bench to Bedside PDF – Contemporary Cardiology

Heart Failure Bench to Bedside PDF


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Table of Contents

Section I Clinical, Physiology and Genetics Changes in Heart Failure
1 Introduction to Heart Failure……. 3
2 Cardiac Function in Heart Failure: The Role of Calcium Cycling……. 15
3 Gene Profiling of the Failing Heart: Epigenetics………… 23

Section II Biochemical and Molecular Changes in Heart Failure
4 Bioenergetics and Metabolic Changes in the Failing Heart……… 45

Section III The Mitochondrial Organelle and the Heart
5 The Multidimensional Role of Mitochondria in Heart Failure……. 73

Section IV Experimental Models of Heart Failure
6 Animal Models of Heart Failure………… 109

Section V Signaling, Stress and Cellular Changes in Heart Failure
7 Signaling Cascades in Heart Failure: From Cardiomyocytes
Growth and Survival to Mitochondrial Signaling Pathways……… 131
8 Cyclic Nucleotides Signaling (Second Messengers)
and Control of Myocardial Function: Effects of Heart Failure……… 161
9 Calcium Signaling: Receptors, Effectors, and Other
Signaling Pathways………. 171
10 Oxidative Stress and Heart Failure………… 195
11 Cardiac Remodeling and Cell Death in Heart Failure……….. 213

Section VI Peripheral Changes and Co-morbid Conditions in Heart Failure
12 Heart Failure and Changes at the Periphery: Vascular,
Inflammation, Neurohormonal, and Renal Systems……….. 235
13 Comorbidities in Heart Failure……………….. 257

Section VII Heart Failure in Children
14 Mechanisms and Clinical Recognition and Management
of Heart Failure in Infants and Children………… 273
15 Mechanical Circulatory Support and Heart Transplantation
in Children with Severe Refractory Heart Failure……… 297

Section VIII Aging and the Failing Heart
16 Basic Mechanisms Mediating Cardiomyopathy
and Heart Failure in Aging…………… 315
17 Heart Failure of Aging: Clinical Considerations…………… 341

Section IX D iagnostic Methodology in Heart Failure
18 D iagnosis of Heart Failure: Evidence-Based Perspective……….. 353
19 “Omics” Application in Heart Failure: Novel Diagnostic and Prognostic
Markers to Understand Pathophysiology and Find New Therapies……………….. 365

Section X Available and Forthcoming Therapies for Heart Failure
20 Treatment of Chronic Heart Failure…………… 379
21 Gene Therapy in Heart Failure: Forthcoming Therapies………… 393
22 Myocardial Cell-Based Regeneration in Heart Failure…………. 409

Section XI Looking to the Future
23 Future Frontiers in Heart Failure……….. 431

Glossary…………… 447
Index……….. 459


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