Harrisons Infectious Diseases PDF
37.56 MB PDF
Despite enormous advances in diagnosis, treatment, and prevention during the twentieth century, physicians caring for patients with infectious diseases today must cope with extraordinary new challenges, including a neverending deluge of new information, the rapid evolution of the microorganisms responsible for these diseases, and formidable time and cost constraints. In no other area of medicine is the differential diagnosis so wide, and often the narrowing of the differential to a precise infection caused by a specific organism with established antimicrobial susceptibilities is a matter of great urgency.
To inform crucial decisions about management, today’s care providers are typically turning to a variety of sources, including colleagues, print publications, and online services. Our goal in publishing Harrison’s Infectious Diseases as a stand-alone volume is to provide practitioners with a single convenient source that quickly yields accurate, accessible, up-to-date information to meet immediate clinical needs and that presents this information in the broader context of the epidemiologic, pathophysiologic, and genetic factors that underlie it. The authors of the chapters herein are acknowledged experts in their fields whose points of view represent decades of medical practice and a comprehensive knowledge of the literature. The specific recommendations of these authorities regarding diagnostic options and therapeutic regimens—including drugs of choice, doses, durations, and alternatives—take into account not just the trends and concerns of the moment but also the longer-term factors and forces that have shaped present circumstances and will continue to influence future developments. Among these forces are the changing prevalence, distribution, features, and management alternatives in different regions of the world; accordingly, these topics are addressed from an international perspective.
Prominent among the 127 chapters in this volume, that on HIV infections and AIDS by Anthony S. Fauci and H. Clifford Lane (Chap. 90) is widely considered to be a classic in the field. Its clinically pragmatic focus, along with its comprehensive and analytical approach to the pathogenesis of HIV disease, has led to its use as the sole complete reference on HIV/AIDS in medical schools. A highly practical chapter by Robert A. Weinstein (Chap. 13) addresses health care–associated infections, a topic of enormous significance in terms of patient care in general and antimicrobial resistance in particular. A superb chapter by Richard C. Reichman (Chap. 86) includes critical information and recommendations regarding the recently licensed human papillomavirus vaccine.Thomas A. Russo and James R. Johnson (Chap. 51) take on the complex area of serious infections caused by gram-negative bacilli, including Escherichia coli.
With a full-color design, this volume offers abundant illustrations that provide key information in a readily understandable format.Two chapters comprise atlases of images that can be invaluable in clinical assessments: Chap. 10 presents images of rashes associated with fever, while Chap. 118 shows blood smears of the various stages of the parasites causing malaria and babesiosis. Selfassessment questions and answers appear in an appendix at the end of the book.
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