The Dental Pulp PDF – Biology Pathology and Regenerative Therapies
The dental pulp has the characteristic of being exclusively the nonmineralized part of a mineralized tooth. This tissue is surrounded by a robust shelllike complex structure that includes dentin and enamel in the crown and cementum in the root. Like most connective tissues, the dental pulp is vascularized and innervated, which constitute important functional differences between the crown and the root. It is also a reservoir of structural fibroblasts (named pulpoblasts long ago by Louis Baume). The pulp complexity is increased by the presence of progenitors (or stem cells) implicated in pulp repair and regeneration.
Inflammatory immune cells are concerned with the destruction of pathogens, cell debris (apoptotic bodies), and/or adverse molecules. Altogether, the heterogeneous cell colonies restore the reparative functions of the dental pulp and consequently the biological approaches of pulp therapies. As an alternative for the surgical or chemical ablation of this tissue and for a limited size of the lesion, pulp capping with biomolecules has been successful. In the case of a more advanced dental destruction, it comes out nowadays that vital pulp regeneration is our next goal. The formation/regeneration of an artificial pulp may be followed by the construction of a homogeneous mineralization, sealing the root canal.
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