Craniofacial Development PDF

Craniofacial Development PDF


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The genesis of this book can be traced to the four editions of its predecessor “Craniofacial Embryology” that has enlightened students in the intricacies of development of the cephalic region for over a quarter of a century. The translation of these previous works into Japanese, German, and Indonesian editions indicates widespread interest in utilizing this text in many parts of the world.
Replacement of that now outdated text is necessitated by the new technologies that have revealed deeper insights into the mechanisms of embryogenesis. The Human Genome Project, now completed, and the explosion of molecular biological knowledge are expanding exponentially our understanding of the development and maldevelopment of the human organism. Moreover, the realm of the once esoteric study of embryology has been vaulted into clinical conscience now that in vitro fertilization, choronic villus sampling, amniocentesis and prenatal ultrasonography and even prenatal fetal surgery are becoming part of clinical practice (Frontispiece). All these aforementioned procedures require an intimate knowledge of the different stages of development, to which this book is dedicated.
The increasing sophistication of prenatal imaging techniques is revealing ever – earlier stages of fetal formation, and significantly, malformation, that may require intervention. To that end, increased emphasis has been placed on anomalous development, allowing for informed decision – making on possible reparative or “genetically engineered” therapy. The combining of “basic science” embryology and fetology with its consequences on clinical practice is one of the aims of this text in breaking barriers between “scientists” and “clinicians” in advancing our understanding the causes, prognosis, and treatments of dysmorphology that is becoming an extensive component of modern medicine and its allied professions.
The advent of computer technology has enabled the portrayal of developmental phenomena as three-dimensional model images in sequential depictions of changes proceeding in the fourth dimension of time. This “morphing” technique is a powerful adjunct to gaining understanding of the complexities of rapidly changing tissues, organs, and relationships occurring during embryogenesis. Some of these animated sequences have been added as an electronic adjunct to the text in the accompanying CD-ROM.

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